Background: Major Depressive Disorder (MDD) is a mental disorder characterized\nby a pervasive and persistent low mood which is accompanied by low\nself-esteem and loss of interest or pleasure in day to day activities that adversely\naffects a personâ??s family, work, and personal life. There is no sufficient\nlaboratory test for the diagnosis of MDD and it is expected that this investigation\nmay be helpful for better diagnosis and management of MDD. We aimed\nto measure serum immunoglobulin levels in MDD patients and control subjects\nto meet the above demand. Methods: For this purpose, we recruited 88\nMDD patients from the department of psychiatry, Bangabandhu Sheikh Mujib\nMedical University, Dhaka and 89 healthy volunteers from Dhaka city matched\nwith age, sex and socioeconomic status to the patient group. Turbidimetry method\nwas applied to measure serum levels of immunoglobulin A, G, and M\nwhere immunoglobulin kit was utilized. Results: The current study revealed\nthat mean serum concentrations of immunoglobulin A, G, and M in patients\nwere found to be 209.07 ± 104.93, 791.50 ± 235.67 and 107.92 ± 47.53 mg/dL\nwhile those were 195.34 ± 92.16, 763.81 ± 175.89 and 99.17 ± 48.78 mg/dL in\ncontrol subjects, respectively. Conclusion: Our result indicates that serum\nconcentrations of immunoglobulin A, G and M were not significant between\nthe groups and further studies are required to establish these findings.
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